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Diazepam usually comes in an ampule that contains 10 milligrams diazepam in an oil-in-water emulsion making up to 2 millilitres. It is also available as a rectal tube containing 2.5 milligrams or 5 milligrams or 10 milligrams diazepam solution. There are no contraindications for diazepam, but the indications include status epilepticus, seizures that last for longer than five minutes, where the seizure continues and eclamptic seizures when the seizure continues for more than two to three minutes or is recurrent. Other indications include symptomatic cocaine toxicity, which may present hypertension, seizure or chest pain. Diazepam depresses the central nervous system and acts as a sedative or anticonvulsant. Care should be taken with dosage and recent dosages should be taken into account when calculating the maximum cumulative dose of diazepam. Diazepam should be used with caution, when alcohol, CNS depressants or antidepressants have been taken as well. These could increase the likelihood of side effects occurring.